After his swearing-in as the fifth president of the fourth republic, Nana Addo Dankwa Akufo-Addo has appointed 37 ministers to serve in various ministries. All the nominees have been sworn into office after going through parliamentary vetting. The following are the new ministers under the Akufo-Addo led administration.
| Minister | Ministry |
| Kojo Oppong Nkrumah | Information |
| Ursula Owusu Ekuful | Communications |
| John Peter Amewu | Energy |
| Cynthia Morrison | Gender, Children and Social Protection |
| Ignatius Baffuor Awuah | Employment and Labour Relations |
| Kofi Addah | Aviation |
| Kofi Dzamesi | Chieftaincy and Religious Affairs |
| Elizabeth Afole Quaye | Ministry of Fisheries and Aquaculture |
| Mustapha Abdul-Hamid | Inner cities and Zongo Development |
| Mavis Hawa Koomson | Special Development Initiative |
| Isaac Kwame Asiamah | Youth and Sports |
| Barbara Oteng Gyasi | Tourism, Culture and Creative Art |
| Prof. George Gyan-Baffour | National Development Planning Commission |
| Cecilia Abena Dapaah | Sanitation and Water Resources |
| Osei Kyei Mensah Bonsu | Parliamentary Affairs |
| Samuel Atta Akyea | Works and Housing |
| Awal Mohammed | Business Development |
| Joe Ghartey | Railways Development |
| Kweku Ofori Asiamah | Transport |
| Kwesi Amoako-Atta | Roads and Highways |
| Kwaku Asomah-Cheremeh | Lands and Natural Resources |
| Prof. Kwabena Frimpong-Boateng | Environment, Science, Technology and Innovation |
| Dan Kwaku Botwe | Regional Reorganization and Development |
| Dr. Anthony Akoto Osei | Monitoring and Evaluation |
| Hajia Alima Mahama | Local Government |
| Dr. Mathew Opoku Prempeh | Education |
| Kwaku Agyeman Manu | Health |
| Gloria Akuffo | Attorney General |
| Shirley Ayorko Botchway | Foreign Affairs |
| Ambrose Derry | Interior |
| Dominic Nitiwul | Defence |
| Dr. Owusu Afriyie Akoto | Agric |
| Kenneth Ofori Atta | Finance |
| Alan John Kyeremanteng | Trade |
| Albert Kan Dapaah | National Security |
| Prof George Yaw Gyan Baffour | Planning |
| Yaw Osafo Marfo | Senior Minister |
